The predetermined primary end-point for this study was motor function measured in two tasks of spontaneous motor behaviors in grid-walking and cylinder tests. These drugs are selective norepinephrine or serotonin reuptake inhibitors indicated for disorders unrelated to stroke. The aim of this study was to evaluate and compare the dose-dependent effect of delayed atomoxetine or fluoxetine therapy (starting on post-stroke day 5), coupled with limited physical exercise (2 hours daily voluntary wheel running post-stroke days 9 to 42), on motor recovery of adult male mice after photothrombotic stroke. Source of Support: This work was partly supported by a National Institutes of Health research grant to VTK (1R01NS106879), Conflict of Interest: NoneĬurrently, there is an unmet need for treatments promoting post-stroke functional recovery. Delayed atomoxetine or fluoxetine treatment coupled with limited voluntary running promotes motor recovery in mice after ischemic strokeįaisal F Alamri 1, Abdullah Al Shoyaib 2, Nausheen Syeara 2, Anisha Paul 2, Srinidhi Jayaraman 2, Serob T Karamyan 3, Thiruma V Arumugam 4, Vardan T Karamyan PhD 5ġ Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA Current address: College of Sciences and Health Profession, King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical, Research Center, Jeddah, Saudi Arabia 2 Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA 3 Department of Pharmacology, Faculty of Pharmacy, Yerevan State Medical University, Yerevan, Armenia 4 Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne, Australia 5 Department of Pharmaceutical Sciences Center for Blood Brain Barrier Research, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA Date of SubmissionĬorrespondence Address: Vardan T Karamyanĭepartment of Pharmaceutical Sciences Center for Blood Brain Barrier Research, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX